Effects of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-rich Fraction on ROS Generation in Proton Beam irradiated Human Colon Carcinoma Cells

Abstract Introduction: Proton beam radiotherapy is an advanced cancer treatment technique, which would reduce the effects of radiation on surrounding healthy cells. The usage radiosensitizers in this technique might further elevate dose towards Material and methods: present study investigated production intracellular reactive oxygen species (ROS) due to presence individual radiosensitizers, such as bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) or baicalein-rich fraction (BRF) from Oroxylum indicum plant, well their combinations, BiONPs-Cis (BC), BiONPs-BRF (BB), BiONPs-Cis-BRF (BCB), HCT-116 colon cells under proton radiotherapy. Results: It was found that ROS Cis at 3 Gy highest, followed by BC, BiONPs, BB, BRF, BCB treatments. properties a radical scavenger, BRF natural compound, contribute lower induction. BC combination were also time-dependent dose-dependent. Conclusions: As prospective alternatives Cis, BiONPs showed capacities be developed for therapy.